To map our graph list onto CDISC ADaM structures for the dummy-data examples, here’s what is proposed for each:
- Kaplan-Meier survival curves — ADTTE
- Forest plots (subgroup / hazard ratio summaries) — ADTTE + ADSL
- Waterfall plots (best % change from baseline) — ADTR / ADRS
- Spider / spaghetti plots (individual subject profiles) — ADLB / ADVS / ADTR / ADQS
- Swimmer plots (treatment duration and response) — ADSL + ADEX + ADRS
- Bar charts (AE incidence, demographics, treatment summaries) — ADAE + ADSL
- Linear/line plots by treatment (mean response over time) — ADEFF / ADLB / ADVS / ADQS
- Mean ± SE/SD over time (labs, vital signs, efficacy, PRO scores) — ADLB / ADVS / ADEFF / ADQS
- Box plots and shift plots (labs by visit/treatment) — ADLB
- Adverse event incidence and patient-profile timeline plots — ADAE (with ADCM/ADEX for full profiles)
- PK concentration-time profiles — ADPC (and ADPP for derived PK parameters)
- Linear/Semi-log plots over time (labs, vital signs) — ADLB / ADVS
Can you suggest any other graphs, or graphs in this list that you don’t need?
Pablo Orosco Joerger and I are planning to use the Pharmaverse ADaM data sets for all of these plots.
Please share views in your comments.
